N-ACYL CYCLIC AMINE DERIVATIVES

摘要

Compounds represented by general formula (I) wherein Ar represents aryl or heteroaryl optionally substituted by halogeno, lower alkyl or lower alkoxy; R1 represents optionally fluorinated C3-6 cycloalkyl; R2 and R4 represent each hydrogen, -(A1)m-NH-B, etc.; R3 and R5 represent each hydrogen, aliphatic C1-6 hydrocarbyl optionally substitute d by lower alkyl, etc.; n is 0 or 1; and X represents oxygen or sulfur. These compounds have selective muscarine M3 receptor antagonism and are excellent in oral activity, duration of action and dynamics in vivo, which makes them useful as safe and efficacious drugs with little side effects for treating respiratory diseases, urologic diseases or digestive diseases.