| 发明名称 |
ARYL-4-ETHYNYL-ISOXAZOLE DERIVATIVES. |
| 摘要 |
<p>The present invention is concerned with aryl-4-ethynyl-isoxazole derivatives of formula (I) wherein R1 to R5 are as described in the specification, R5 representing an optionally substituted aryl or heteroaryl. It has been found that this class of compounds show high affinity and selectivity for GABA A α5 receptor binding sites, being useful as cognitive enhancer or for the treatment of cognitive disorders like Alzheimer's disease.</p> |
| 申请公布号 |
MX2008014796(A) |
申请公布日期 |
2008.12.02 |
| 申请号 |
MX20080014796 |
申请日期 |
2007.05.21 |
| 申请人 |
F. HOFFMANN-LA ROCHE AG. |
发明人 |
BERND BUETTELMANN.;ANDREW THOMAS;HENNER KNUST |
| 分类号 |
C07D261/08;A61K31/42;A61K31/422;A61P25/28;C07D413/06;C07D413/12;C07D413/14;C07D417/14;C07D471/04 |
主分类号 |
C07D261/08 |
| 代理机构 |
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