发明名称 |
COMPETITIVE INHIBITORS OF GLYOXALASE I AND METHOD OF GENERATING SUCH COMPETITIVE INHIBITORS INSIDE TUMOR CELLS |
摘要 |
The present invention provides a compound having structure (I) wherein S* is S=O or O=S=O; and wherein R1 is selected from the group consisting of (C1-C9) alkyl, (C3-C8) cycloalkyl, (C5-C7) cycloalkenyl, and (C6-C20) aryl substituted with halogen or (C1-C18) alkyl; and wherein R2 is selected from the group consisting of alkyl, (C1-C9) alkyl , (C3-C8) cycloalkyl, (C5-C7) cycloalkenyl, and (C6-C20) aryl substituted with hologen or (C1-C18) alkyl. Also provided are various method s of using the compositions of the present invention.
|
申请公布号 |
CA2317565(C) |
申请公布日期 |
2008.12.02 |
申请号 |
CA19992317565 |
申请日期 |
1999.01.07 |
申请人 |
UNIVERSITY OF MARYLAND BALTIMORE COUNTY |
发明人 |
CREIGHTON, DONALD;KAVARANA, MALCOLM J.;HAMILTON, DIANA S. |
分类号 |
C07C381/14;A61K31/27;A61P35/00;C07C333/04;C07C333/08;C07C333/12 |
主分类号 |
C07C381/14 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|