发明名称 |
Method for generating a net analyte signal calibration model and uses thereof |
摘要 |
A method for generating a net analyte signal calibration model for use in detecting and/or quantifying the amount of an analyte in a test subject. The net analyte signal can be generated by providing a set of in vivo infrared spectra for a test subject during a period in which an analyte concentration is essentially constant; calculating an optimal subspace of spectra that at least substantially describes all non-analyte dependent spectral variance in the in vivo spectra; providing a pure component infrared spectrum for the analyte; and calculating a net analyte signal spectrum from a data set comprising the optimal subspace spectra and the pure analyte spectrum. The net analyte signal calibration model can be used, for example, in measuring the concentration of analyte in a test subject, and/or for evaluating the analytical significance of an in vivo multivariate calibration model. |
申请公布号 |
US7460895(B2) |
申请公布日期 |
2008.12.02 |
申请号 |
US20050042817 |
申请日期 |
2005.01.24 |
申请人 |
UNIVERSITY OF IOWA RESEARCH FOUNDATION |
发明人 |
ARNOLD MARK A.;OLESBERG JONATHON T. |
分类号 |
A61B5/1455;G01J3/00;G12B13/00 |
主分类号 |
A61B5/1455 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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