| 发明名称 |
MUTATED HOXB4 PROTEINS WITH IMPROVED STABILITY, AND METHODS OF USE THEREOF |
| 摘要 |
A polypeptide, the amino acid sequence of which comprises a sequence as set forth in Figure 15A (SEQ ID NO: *), including at least one mutation with in the degron domain of the polypeptide encompassed between positions 1 and 35 of the sequence, wherein said at least one mutation reduces the susceptibility of the polypeptide to ubiquitin-proteasome degradation.
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| 申请公布号 |
CA2590593(A1) |
申请公布日期 |
2008.12.01 |
| 申请号 |
CA20072590593 |
申请日期 |
2007.06.01 |
| 申请人 |
ROY, DENIS-CLAUDE;SAUVAGEAU, GUY;HUMPHRIES, KEITH R.;BESLU, NATHALIE |
发明人 |
ROY, DENIS-CLAUDE;SAUVAGEAU, GUY;HUMPHRIES, KEITH;BESLU, NATHALIE |
| 分类号 |
C12N15/12;A61K38/17;A61K48/00;C07K14/47;C07K16/18;C12N5/02;C12N5/10;C12N15/63;C12P21/02;C12Q1/34;G01N33/68 |
主分类号 |
C12N15/12 |
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