| 摘要 |
<p>MUSCARINIC ACETYLCHOLINE RECEPTOR ANTAGONISTS Muscarinic Acetylcholine Receptor Antagonists of Formula (I) are provided herewith: wherein interalia R1- represents an anion associated with the positive charge of the N atom; R2 and R3 are independently selected from phenyl and heteroaryl; and R4 is selected from (C1-C6)alkyl, (C3-C12)cycloalkyl, (C1-C6)alkyl(C3-C12)cycloalkyl, aryl, heteroaryl,(C1-C6)alkyl-aryl, (C1-C6])alkyl heteroaryl, -OR5, -CH2OR5, - CH2OH, -CN, -CF3, -CH2O(CO)R6, -CO2R7, -CH2NH2, -CH2N(R7)SO2R5, -SO2N(R7)(R8), - CON(R7)(R8), -CH2N(R8)CO(R6), -CH2N(R8)SO2(R6), -CH2N(R8)CO2(R5), or - CH2N(R8)CONH(R7).</p> |
