| 摘要 |
PROBLEM TO BE SOLVED: To provide an industrially suitable method for producing 5-halogenoindole in a high yield from 2-(5-halogeno-2-nitrophenyl)-2-cyanoacetate that can be easily obtained in a simple way. SOLUTION: The method of producing the 5-halogenoindole is characterized by including (A) a first step wherein the 2-(5-halogeno-2-nitrophenyl)-2- cyanoacetate is changed to 5-halogeno-2-nitrobenzylcyanide by decarboxylation, and (B) a second step wherein the 5-halogeno-2- nitrobenzylcyanide is cyclized in the presence of a catalyst under blowing hydrogen. COPYRIGHT: (C)2009,JPO&INPIT
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