发明名称 |
MODIFIED SELF-ASSEMBLING PEPTIDES |
摘要 |
The present invention provides a self-assembling peptide comprising: (a) a first amino acid domain that mediates self-assembly, wherein the domain comprises alternating hydrophobic and hydrophilic amino acids that are complementary and structurally compatible and self-assemble into a macroscopic structure when present in unmodified form; and (b) a second amino acid domain that does not mediate self- assembly in isolated form, wherein the second amino acid domain comprises at least one minimal biologically active sequence. Such self-assembling peptides are described herein as "modified self-assembling peptides." The present invention also provides pharmaceutical compositions, kits and maxtrices comprising a modified self-assembling peptide, and methods of using and making such compositions, kits and matrices. |
申请公布号 |
WO2008039483(A3) |
申请公布日期 |
2008.11.27 |
申请号 |
WO2007US20754 |
申请日期 |
2007.09.26 |
申请人 |
MASSACHUSETTS INSTITUTE OF TECHNOLOGY;HORII, AKIHIRO;ZHANG, SHUGUANG;WANG, XIUMEI;GELAIN, FABRIZIO |
发明人 |
HORII, AKIHIRO;ZHANG, SHUGUANG;WANG, XIUMEI;GELAIN, FABRIZIO |
分类号 |
C07K19/00;A61L15/00;C07K14/00;C07K17/02;C12N11/06 |
主分类号 |
C07K19/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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