发明名称 AMPHIPATHIC MOLECULE, MOLECULAR AGGREGATE COMPRISING THE AMPHIPATHIC MOLECULE, AND USE OF THE MOLECULAR AGGREGATE
摘要 <p>Disclosed is an amphipathic molecule having two or more zwitterionic functional groups in its hydrophilic moiety. Also disclosed is a molecular aggregate comprising the amphipathic molecule as a constituent lipid. The molecular aggregate can form a stable vesicular structure under a physiological pH environment to carry a substance of interest in the vesicular structure, and can release the substance of interest to the outside of the vesicular structure when the vesicular structure is deformed under an acidic pH environment. The molecular aggregate can be used as a transporter for a drug, a probe, a nucleic acid, a protein or the like.</p>
申请公布号 WO2008143339(A1) 申请公布日期 2008.11.27
申请号 WO2008JP59499 申请日期 2008.05.16
申请人 WASEDA UNIVERSITY;JCR PHARMACEUTICALS CO., LTD.;TAKEOKA, SHINJI;OBATA, YOSUKE;TAJIMA, SHOJI;ITO, MANABU;MIZUNO, ATSUSHI;NISHIYAMA, NATSUKO;TAKEUCHI, YOSHITO 发明人 TAKEOKA, SHINJI;OBATA, YOSUKE;TAJIMA, SHOJI;ITO, MANABU;MIZUNO, ATSUSHI;NISHIYAMA, NATSUKO;TAKEUCHI, YOSHITO
分类号 C07K2/00;A61K38/43;A61K47/18;A61K47/42;C07C229/16;C07C237/12;C12N15/09 主分类号 C07K2/00
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