发明名称 |
FARNESYLAMINE DERIVATIVES AND METHODS OF USE |
摘要 |
<p>The present invention concerns farnesylamine derivatives, compositions containing these compounds, and methods of using these compounds and compositions as inhibitors of røs-mediated signal transduction and inhibitors of aberrant cell growth, e.g., as anti-cancer agents, as well as anti-fungal agents. Other non-malignant diseases characterized by proliferation of cells that may be treated using the farneylamine derivatives of the include, but are not limited to, cirrhosis of the liver; graft rejection; restenosis; and disorders characterized by a proliferation of T cells such as autoimmune diseases, e.g., type 1 diabetes, lupus and multiple sclerosis.</p> |
申请公布号 |
WO2008143947(A1) |
申请公布日期 |
2008.11.27 |
申请号 |
WO2008US06251 |
申请日期 |
2008.05.14 |
申请人 |
UNIVERSITY OF SOUTH FLORIDA;KOTHAPALLI, RAVI;BISHT, KIRPAL, S. |
发明人 |
KOTHAPALLI, RAVI;BISHT, KIRPAL, S. |
分类号 |
A61K38/00;A61K38/54;C07H21/02;C07K7/06;C12N15/12 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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