NOVEL RABBIT ANTIBODY HUMANIZATION METHODS AND HUMANIZED RABBIT ANTIBODIES
摘要
The present invention is directed to novel and improved methods for humanizing rabbit heavy and light variable regions. The resulting humanized rabbit heavy and light chains and antibodies and antibody fragments containing are well suited for use in immunotherapy and immunodiagnosis as they retain the antigen binding affinity of the parent antibody and based on their very high level of sequence identity to human antibody sequences should be essentially non-immunogenic in humans. The invention exemplifies the protocol for the manufacture of therapeutic humanized anti-human TNF-alpha and anti-human IL-6 antibodies.
申请公布号
WO2008144757(A1)
申请公布日期
2008.11.27
申请号
WO2008US64421
申请日期
2008.05.21
申请人
ALDER BIOPHARMACEUTICALS, INC.;LATHAM, JOHN;KOVACEVICH, BRIAN