NEUES VERFAHREN ZUR HERSTELLUNG VON VIRUS-ÄHNLICHEN PARTIKELN DES MENSCHEN-PAPILLOMAVIRUS MIT VERBESSERTEN EIGENSCHAFTEN

摘要

Human papillomavirus virus-like particles (VLPs) are subjected to various maturation conditions, including incubation at higher temperatures, exposure to soluble metals or thios-oxidation. The resultant matured VLPs are more stable, and can be used to make a vaccine formulation with increased shelf life and higher potency.