发明名称 |
DETOXIFIED PNEUMOCOCCAL NEURAMINIDASE AND USES THEREOF |
摘要 |
<p>Provided herein are compositions designed to reduce or prevent pneuomococcal infections, nasal carriage, nasal colonization, and central nervous system invasion. Provided herein is a composition comprising a polypeptide comprising the amino acid sequence of SEQ ID NO: 19 or a variant thereof that can elicit an anti-neuraminidase immune response. Further provided are methods of making and using the compositions disclosed herein. Specifically provided are methods of generating antibodies in a subject comprising administering to the subject an agent or composition taught herein. Also provided are methods of reducing or preventing nasal carriage or pneumococcal infection in a subject comprising administering to the subject a composition taught herein.</p> |
申请公布号 |
CA2688009(A1) |
申请公布日期 |
2008.11.27 |
申请号 |
CA20072688009 |
申请日期 |
2007.05.23 |
申请人 |
THE UAB RESEARCH FOUDATION |
发明人 |
BRILES, DAVID E.;HOLLINGSHEAD, SUSAN K. |
分类号 |
C12N9/24;A61K39/09 |
主分类号 |
C12N9/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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