IDENTIFICATION OF OXIDATIVELY MODIFIED PEPTIDE SEQUENCES IN THE PROTEOME

摘要

The invention relates to a method of identifying protein targets that undergo oxidative modification and the specific peptide sequences bearing oxidation-induced modifications The method further relates to exposing the protein to a condition that results in the modification of an amino acid in the protein, and determining the oxidation state of the protein after exposure to the condition that results in oxidation-induced modification of an amino acid in the protein The method further compares the oxidation state of the protein before and after exposure to the condition