Fluorinated 3'-Deoxythymidine Derivatives, a Method for Their Preparation and Their Use

摘要

The invention relates to new side chain-fluorinated 3'-deoxythymidine derivatives of the general formula I or physiological acceptable esters thereof, wherein R-CH218F; CH18F2; CH2F or CHF2 and Y-H, N3 or Hal. The invention also relates to a simple and efficient method for the preparation of these 3'-deoxythymidines of formula I and to the use of the 18F-containing compounds of formula I or of a pharmaceutical composition comprising these compounds for the diagnosis of tumors in positron emission tomography (PET).