摘要 |
<p>This invention pertains generally to the field of therapeutic compounds, and more particularly, to certain bicyclosulfonyl acid (BCSA) compounds which act as inhibitors of Tumour Necrosis Factor-a Converting Enzyme (TACE). The compounds are useful in the treatment of conditions mediated by TNF-a, such as rheumatoid arthritis; inflammation; psoriasis; septic shock; graft rejection; cachexia; anorexia; congestive heart failure; post ischaemic reperfusion injury; inflammatory disease of the central nervous system; inflammatory bowel disease; insulin resistance; HIV infection; cancer; chronic obstructive pulmonary disease (COPD); and asthma. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in</p> |
申请人 |
INHIBOX LTD.;JIRGENSONS, AIGARS;LEITIS, GUNDARS;KALVINSH, IVARS;ROBINSON, DANIEL;FINN, PAUL;KHAN, NAGMA |
发明人 |
JIRGENSONS, AIGARS;LEITIS, GUNDARS;KALVINSH, IVARS;ROBINSON, DANIEL;FINN, PAUL;KHAN, NAGMA |