NOVEL PROCESSES FOR PREPARING 6-(DIFLUOROMETHOXY) [1]BENZOFURO [3,2-C]PYRIDINE-9-CARBALDEHYDE, A NOVEL INTERMEDIATE FOR THE SYNTHESIS OF PDE IV INHIBITORS

摘要

The present invention relates to novel processes for preparing 6-(difluoromethoxy)[1] benzofuro[3,2-c]pyridine-9-carbaldehyde, which is a novel and useful intermediate for preparing compounds with PDE4 inhibitory activity, such as 3,5-dichloro-4-(6- difluoromethoxybenzo[4,5] furo [3,2-c]pyridin-9-ylcarboxamido)-1 -pyridiniumolate.