发明名称 |
METHODS FOR HIGH SENSITIVITY DETECTION OF GENETIC POLYMORPHISMS |
摘要 |
Multiplex PCR-based methods for detecting a variant polynucleotide having a nucleotide sequence differing from the wild-type nucleotide sequence of a nucleic acid molecule, wherein the variant polynucleotide is in a sample containing an excess of the wild-type nucleic acid molecule. The methods are particularly useful for detection of deletions from, or translocations and inversions in, genomic DNA. The susceptibility to, diagnosis of, and progression of a disease clinically related to the occurrence of such polymorphisms in an individual may also be confirmed and monitored using the multiplex PCR-based methods or by detecting RNA fusion transcripts in a sample that correspond to previously identified deletions, translocations or inversions in genomic DNA.
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申请公布号 |
WO2008016615(A3) |
申请公布日期 |
2008.11.27 |
申请号 |
WO2007US17128 |
申请日期 |
2007.07.31 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;CARSON, DENNIS, A.;LIU, YU-TSUENG |
发明人 |
CARSON, DENNIS, A.;LIU, YU-TSUENG |
分类号 |
C12Q1/68;C12P19/34 |
主分类号 |
C12Q1/68 |
代理机构 |
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地址 |
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