A device for manipulating body tissue comprises a base structure and at least one tubular member having a proximal end and an orientable distal end that defines a seat for supporting a surgical instrument, in which the tubular member is connected to the base structure. An actuation mechanism is suitable for orientating the distal end of the tubular member to take it into certain operative configurations. The actuation mechanism is also connected to the base structure. Means are also foreseen for the connection of the base structure to a distal end portion of an insertion tube of an endoscope or laparoscope, so that the actuation mechanism and the tubular member are arranged outside the insertion tube. The tubular member interacts with the actuation mechanism so that a movement of an actuation portion of the tubular member with respect to the base structure leads to the orientation of the orientable end.
