发明名称 |
PREPARATION OF OPIATE ANALGESICS BY REDUCTIVE ALKYLATION |
摘要 |
A process for preparing a compound of formula (A), (B) or (C): wherein P is H, CH3 or a hydroxyl protecting group; X is O, a protected ketone, OH, a protected hydroxyl group or H; Y is OH, a protected hydroxyl group or H; W is C(CH3)2OH, (CH3)(C(CH3)3)OH or COCH3; Z is C2-C10 alkyl or C2-C10 arylalkyl; and is a single bond or a double bond, is disclosed. The process includes reductive alkylation in the presence of hydrogen and a reductive alkylation catalyst. |
申请公布号 |
ZA200701784(B) |
申请公布日期 |
2008.11.26 |
申请号 |
ZA20070001784 |
申请日期 |
2007.02.28 |
申请人 |
JOHNSON MATTHEY PUBLIC LIMITED COMPANY |
发明人 |
GOODWIN, NEIL JOHN, MITCHELL, MELVILLE;THOMSON, NEIL KENNETH;WILSON, GEORGE SCOTT;YOUNG, MAUREEN JOAN |
分类号 |
C07D;C07D221/28;C07D489/02;C07D489/08 |
主分类号 |
C07D |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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