发明名称 |
Endothelin a receptor (ETA) antogonists in combination with phosphodiesterase 5 inhibitors (PDE5) and uses thereof |
摘要 |
The invention relates generally to combination therapies comprising an endothelin A receptor (ET<SUB>A</SUB>) antagonist and a phosphodiesterase 5 (PDE5) inhibitor, pharmaceutical compositions comprising ET<SUB>A</SUB> antagonist and PDE5 inhibitor and methods of treating various disorders comprising administering an ET<SUB>A</SUB> antagonist and a PDE5 inhibitor. In particular, the combination therapies and pharmaceutical compositions are useful for the treatment and/or prevention of cardiac disorders such as pulmonary arterial hypertension (PAH). |
申请公布号 |
ZA200702132(B) |
申请公布日期 |
2008.11.26 |
申请号 |
ZA20070002132 |
申请日期 |
2007.03.13 |
申请人 |
ENCYSIVE PHARMACEUTICALS |
发明人 |
KEYSER, DONALD JEFFREY;DIXON, RICHARD |
分类号 |
A61K |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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