发明名称 |
Compounds and methods for modulating functions of classical cadherins |
摘要 |
Modulating agents and methods for enhancing or inhibiting classical cadherin-mediated functions are provided. The modulating agents comprise at least a tryptophan-containing cell adhesion recognition sequence of a classical cadherin molecule, a conservative analogue or peptidomimetic thereof, or an antibody or fragment thereof that specifically binds to such a cell adhesion recognition sequence. Modulating agents may additionally comprise one or more cell adhesion recognition sequences recognized by cadherins and/or other adhesion molecules. Such modulating agents may, but need not, be linked to a targeting agent, pharmaceutically active substance and/or support material.
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申请公布号 |
US7456153(B2) |
申请公布日期 |
2008.11.25 |
申请号 |
US20030714556 |
申请日期 |
2003.11.14 |
申请人 |
ADHEREX TECHNOLOGIES INC. |
发明人 |
BLASCHUK OREST W.;MICHAUD STEPHANIE D. |
分类号 |
A61K38/12;A61K38/00;A61K38/10;A61K39/395;C07D211/58;C07K5/103;C07K5/113;C07K5/117;C07K14/705 |
主分类号 |
A61K38/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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