| 发明名称 |
Humanized antibody |
| 摘要 |
The current invention provides new human variable chain framework regions and humanized antibodies comprising the framework regions. The invention also provides a new method of identifying framework acceptor regions in framework sequences for backmutation to graft a donor sequence to the human framework.
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| 申请公布号 |
US7456260(B2) |
申请公布日期 |
2008.11.25 |
| 申请号 |
US20040515149 |
申请日期 |
2004.11.18 |
| 申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES;THE UNIVERSITY OF READING |
发明人 |
RYBAK SUSANNA M.;KRAUSS JUERGEN;ARNDT MICHAELA;MARTIN ANDREW C. R. |
| 分类号 |
C07K16/00;C07H21/04;C07K16/28;C07K16/46;C12N15/13;C12P21/08 |
主分类号 |
C07K16/00 |
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