PHARMACEUTICAL COMPOSITION FOR THE PREVENTION OR TREATMENT OF TGFB1-RELATED DISEASES COMPRISING DOWN REGULATORS OF GALPHA 12/GALPHA 13 PROTEIN FUNCTION

摘要

A pharmaceutical composition of preventing or treating diseases related to a transforming growth factor beta 1(TGFb1) is provided to prevent, reduce and cure diseases related to a transforming growth factor beta 1(TGFb1) such as fiberization, cirrhosis, immunization disease and tumor by suppressing expression of the transforming growth factor beta 1(TGFb1) by controlling a function of the Ga12/Ga13 protein. A pharmaceutical composition of preventing reducing and curing diseases related to a transforming growth factor beta 1(TGFb1) includes a Ga12 protein function inhibitor and a Ga13 protein function inhibitor. The Ga12 protein function inhibitor and the Ga13 protein function inhibitor is delivered using liposome, virus, gene gun, polymer, ultrasonic wave and electroporation.