PHOSPHOLIPID NANOSPHERES FOR SOLUBILIZATION OF DITERPENOID ALKALOID AND PREPARATION

摘要

A diterpenoid alkaloid group drug solution is provided to become soluble in a water phase at a high concentration without a surfactant harmfulness to human body by including a lipid nano particle, to have a size distribution of a uniform particle and to be used as an injection having a high safety. A diterpenoid alkaloid group drug solution is manufactured by dispersing diterpenoid alkaloid group drug having a solid solution state and lipid nano particles in an aquatic medium. The lipid nano particles are manufactured by dispersing a lipid mixture comprising phospholipid, sterols, cationic lipid or anionic lipid and polyethylene glycol in an organic solvent. A mixing ratio of the phospholipid, the sterols, the cationic lipid or the anionic lipid and the polyethylene glycol is 3 ~ 8 : 2 ~ 6 : 1 ~ 5 : 0 ~ 3.