| 摘要 |
A diagnostic method for bladder urethelial carcinoma includes obtaining an isolated nucleotide sample from a subject and detecting the promoter methylation of at least three tumor suppressor genes selected form group consisting of DAPK, RAR-beta, pl4, p73, MGMT, APC, SOCS-I, BRCA-I, and FHIT. than 50,000 newly diagnosed cases in the United States alone each year. Although superficial bladder transitional cell carcinoma (TCC) can be removed by transurethral resection, more than 50% recur, approximately 30% progress to invasive disease, and up to 30% of patients die from the disease. Current surveillance of patients with bladder TCC is performed by voided urine cytology followed by cytoscopy. Although high-grade flat urethelial carcinoma in situ (CIS) can be readily detected in urine by cytology, the sensitivity for cytological detection of papillary bladder TCC in urine is less than 30% due to overlapping cytomorphologic features between papillary TCC and benign/reactive processes. |
