发明名称 |
RNA SILENCING COMPOSITIONS AND METHODS FOR THE TREATMENT OF HUNTINGTON'S DISEASE |
摘要 |
The present invention relates to the discovery of an effective treatment for a variety of Huntington's disease (HD). The present invention utilizes RNA silencing technology (e.g. RNAi) against single nucleotide polymorphisms (SNPs) in the Huntingtin (htt) gene encoding the dominant, gain-of-function mutant Huntington protein, thereby resulting in an effective treatment for the gain-of-function disease. |
申请公布号 |
WO2008005562(A3) |
申请公布日期 |
2008.11.20 |
申请号 |
WO2007US15638 |
申请日期 |
2007.07.09 |
申请人 |
UNIVERSITY OF MASSACHUSETTS;ARONIN, NEIL;ZAMORE, PHILLIP, D. |
发明人 |
ARONIN, NEIL;ZAMORE, PHILLIP, D. |
分类号 |
C12Q1/68;A01N43/04;C07H21/02;C07H21/04;C12N15/11;C12N15/113;C12N15/63;C12N15/88;C12P19/34 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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