| 发明名称 |
MODIFIED POLYMERASES AND ATTENUATED VIRUSES AND METHODS OF USE THEREOF |
| 摘要 |
<p>Compositions and methods involving modified viral polymerases with one or more substitutions of different amino acids at conserved regions of the pol ymerase result in enzymes with varying rates and fidelity of replication A u niversally applicable polymerase mechanism based strategy for the production of attenuated viruses and anti-viral vaccines is also disclosed</p> |
| 申请公布号 |
CA2673535(A1) |
申请公布日期 |
2008.11.20 |
| 申请号 |
CA20072673535 |
申请日期 |
2007.12.24 |
| 申请人 |
THE PENN STATE RESEARCH FOUNDATION |
发明人 |
ARNOLD, JAMIE;CASTRO, CHRISTIAN;CAMERON, CRAIG E. |
| 分类号 |
C12N15/54;A61K39/13;A61K39/145;A61K39/21;C12N7/01;C12N7/04;C12N9/12 |
主分类号 |
C12N15/54 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
