HOX-GENE EXPRESSION AS A BIOMARKER FOR IGF-1R THERAPEUTICS
摘要
This invention provides methods for treating or preventing the onset of a tumor in a subject, wherein the tumor is determined to overexpress a Hox gene, including administering to the subject a therapeutically or prophylactically effective amount of an insulin-like growth factor-1 receptor (IGF-1R) antagonist. The invention also provides methods for determining whether a tumor in a subject is amenable to treatment with an IGF-1R antagonist including determining whether the tumor overexpresses a Hox gene, wherein overexpression of the Hox gene indicates that the tumor is amenable to treatment with an IGF-1R inhibitor.
申请公布号
WO2008115470(A3)
申请公布日期
2008.11.20
申请号
WO2008US03494
申请日期
2008.03.17
申请人
EAST CAROLINA UNIVERSITY;BERTRAND, FRED, EDMOND, III;WHELAN, JARRETT, THOMAS
发明人
BERTRAND, FRED, EDMOND, III;WHELAN, JARRETT, THOMAS