| 摘要 |
A secured transdermal delivery system, applicable to both matrix and reservoir patches, for preventing misuse of medications embedded within and affixed to transdermal patches. The secured transdermal delivery system includes a backing supporting a pharmaceutical composition and one or more security agents adapted to modify the pharmacophore of the pharmaceutical composition. The security agent is separated from the pharmaceutical composition by one or more dissolving security layers which define one or more security reservoirs within the patch.
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