发明名称 |
Detomidine Hydrochloride Crystallization Method |
摘要 |
A method of isolating detomidine (I) hydrochloride as a crystalline salt is provided. The method comprises hydrogenating in the presence of a catalyst of compound of formula (II) in aqueous solution comprising hydrochloric acid, concentrating the solution by distillation, optionally adding hydrochloric acid to the concentrated solution, cooling the concentrated solution and recovering the crystallized detomidine hydrochloride. The product can be recovered directly from aqueous solution with
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申请公布号 |
US2008287685(A1) |
申请公布日期 |
2008.11.20 |
申请号 |
US20060911181 |
申请日期 |
2006.04.13 |
申请人 |
KARJALAINEN ARTO;PARHI SEPPO |
发明人 |
KARJALAINEN ARTO;PARHI SEPPO |
分类号 |
C07D233/58;C07D;C07D233/54 |
主分类号 |
C07D233/58 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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