Nfkb Transcriptional Activity Inhibitory Agent and Anti-Inflammatory Agent and a Steroid Action Enhancing Agent

摘要

It is intended to surely and effectively inhibit the transcriptional activity of NFkappaB and to obtain a more effective anti-inflammatory effect. Further, it is intended to obtain an equivalent effect even if the amount used of a steroid agent is reduced. An agent is characterized by containing MTI-II, especially a nucleic acid sequence of SEQ ID NO: 1, or a peptide of SEQ ID NO: 2. This MTI-II peptide is preferably a peptide containing at least an acidic amino acid domain (SEQ ID NO: 3). Further, a steroid agent such as triamcinolone acetonide is used concomitantly with MTI-II, especially the nucleic acid sequence of SEQ ID NO: 1 or the peptide of SEQ ID NO: 2.