NON-HUMAN EMBRYONIC STEM CELL LINES AND TRANSGENIC ANIMALS DERIVED FROM THEM

摘要

Stem cells and stem cell lines, derived from animal embryos, such as from goat, are disclosed along with methods of producing such cells and cell lines. Also described are methods of using such cells, and cell lines, for the generation of transgenic animals, such as transgenic goats. Further disclosed are transgenic animals derived from such cells, and cell lines, wherein said animals comprise a heterologous transgene that expresses a selected protein, especially where said protein is produced in the milk or urine of the transgenic animal. An animal model for studying disease or for insertion of stems cells or cells derived from stem cells is also presented.