发明名称 |
ANTI-IDIOTYPE MONOCLONAL ANTIBODIES AS MIMOTOPES OF THE HIV GP120 ANTIGEN |
摘要 |
<p>Novel anti-idiotype monoclonal antibodies are described which are capable of specifically reacting with the idiotype of human anti-gpl20 antibodies, of inhibiting the binding between the gpl20 antigen and human anti-gpl20 antibodies, and of evoking a neutralising anti-gpl20 immune response in an animal host to which they are administered. The anti-idiotype antibodies of the invention can be identified based on the amino acid sequences of the variable portions of their light and heavy chains. In addition, a method for obtaining a panel of anti-idiotype monoclonal antibodies, expression vectors and transformed host cells usable in a recombinant DNA procedure in order to generate the aforesaid anti-idiotype monoclonal antibodies, as well as the therapeutic, prophylactic and diagnostic use of such antibodies are disclosed.</p> |
申请公布号 |
WO2008093280(A3) |
申请公布日期 |
2008.11.20 |
申请号 |
WO2008IB50307 |
申请日期 |
2008.01.29 |
申请人 |
POMONA BIOTECHNOLOGIES LLC;BURIONI, ROBERTO;CLEMENTI, MASSIMO |
发明人 |
BURIONI, ROBERTO;CLEMENTI, MASSIMO |
分类号 |
C07K16/42;A61K39/395;A61P31/18;C12N1/21;C12N5/12;C12N15/13;G01N33/563;G01N33/577 |
主分类号 |
C07K16/42 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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