METHOD FOR PRODUCTION OF OPTICALLY ACTIVE CARBOXYLIC ACID ESTER

摘要

Disclosed is a method for producing an optically active carboxylic acid ester directly from a racemic secondary alcohol and a carboxylic acid. Also disclosed is a method for optically resolving a racemic secondary alcohol in the same method as the above-mentioned method. One of the enantiomers of a racemic secondary alcohol and a carboxylic acid are subjected to the dehydrative condensation in the presence of benzoic anhydride or a derivative thereof by using (-)-tetramisole, (+)-tetramisole, (-)-benzotetramisole, (+)-benzotetramisole or the like as an asymmetric esterification catalyst, thereby producing an optically active carboxylic acid ester; and the other of the enantiomers, which is unreacted, is optically resolved.