Pyrazole Derivatives as Cb1 Modulators

摘要

The present invention relates to compounds of formula I wherein R¹ represents a group R⁵O- in which R⁵ represents a C_3-7alkyl group substituted by one or more fluoro or R⁵ represents a C_3-7alkylsulphonyl group which is optionally substituted by one or more fluoro; R² represents a C_1-4alkyl group, hydroxy, fluoro, chloro or cyano wherein each R² is independently selected when n is >1; R³ represents a) cyclohexyl optionally substituted by one or more of the following: hydroxy, fluoro, amino, mono or diC_1-3alkylamino, carboxy or a C_1-4alkoxycarbonyl group b) piperidino substituted by one or more hydroxy c) unsubstituted piperidino but only when one of the following applies: R⁴ represents cyano or R¹ represents 3-fluoropropylsulphonyloxy or R¹ represents 3,3,3-trifluoropropoxy or R¹ represents 3-fluoropropoxy or R² is methyl d) phenyl substituted by one or more of the following: hydroxy, halo or a C_1-4alkyl group e) pyridyl substituted by a C_1-4alkyl group or f) a C_4-9alkyl group; R⁴ represents cyano or methyl; and n is 1, 2 or 3 and pharmaceutically acceptable salts thereof and processes for preparing such compounds, their use in the treatment of obesity, psychiatric and neurological disorders, to methods for their therapeutic use and to pharmaceutical compositions containing them.