发明名称 |
SOX11 EXPRESSION IN MALIGNANT LYMPHOMAS |
摘要 |
The present invention provides a binding moiety which selectively binds to Sox1 1 protein and/or mRNA for imaging, diagnosis or prognosis of lymphomas, such as mantle cell lymphomas (MCL) and diffuse large B-cell lymphoma (DLBCL). Optionally, the moiety is an antibody or antigen-binding fragment thereof. Advantageously, moiety comprises a further, readily detectable moiety. The invention also provides methods of imaging lymphomas cells as well as methods of diagnosing or prognosing lymphomas in an individual. A further aspect of the present invention provides a method of identifying cells associated with lymphomas, the method comprising analysing the pattern of gene expression in a sample of cells to be tested and comparing it to the pattern of gene expression in a sample of known lymphomas cells. Preferably, the cells to be tested are identified as lymphoma cells if the expression of Sox11 is upregulated compared to normal B-cells. |
申请公布号 |
WO2008139169(A1) |
申请公布日期 |
2008.11.20 |
申请号 |
WO2008GB01625 |
申请日期 |
2008.05.12 |
申请人 |
IMMUNOVIA AB;BORREBAECK, CARL, ARNE, KRISTER;EK, SARA |
发明人 |
BORREBAECK, CARL, ARNE, KRISTER;EK, SARA |
分类号 |
C12Q1/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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