BONE TARGETED ALKALINE PHOSPHATASE, KITS AND METHODS OF USE THEREOF
摘要
<p>A bone targeted alkaline phosphatase comprising a polypeptide having the structure : Z-sALP-Y-spacer-X-W<SUB>n</SUB>-V, wherein sALP is the extracellular domain of the alkaline phosphatase; wherein V is absent or is an amino acid sequence of at least one amino acid; X is absent or is an amino acid sequence of at least one amino acid; Y is absent or is an amino acid sequence of at least one amino acid; Z is absent or is an amino acid sequence of at least one amino acid; and W<SUB>n</SUB> is a polyaspartate or a polyglutamate wherein n = 10 to 16. Kits and methods of use thereof.</p>
