PHOSPHOLIPID NANOSPHERES FOR SOLUBILIZATION OF DITERPENOID ALKALOID AND PREPARATION

摘要

Disclosed are a diterpenoid alkaloid-based drug solution comprising lipid nanospheres and a preparation method thereof. More specifically, the present invention provides a diterpenoid alkaloid-based drug solution comprising lipid nanospheres prepared by dispersing lipid nanospheres, which are formed by dispersing a diterpenoid alkaloid-based drug such as paclitaxel, docetaxel, etc. in solid solution state and biocompatible lipids comprising phospholipid, sterol, cationic or anionic lipid and polyethylene glycol with a predetermined proportion in an organic solvent, in an aqueous medium, and a preparation method thereof.