NOVEL IMMUNOTHERAPEUTIC MYCOBACTERIA, PHARMACEUTIC FORMULATIONS AND USES THEREOF

摘要

This invention provides genetically modified Mycobacterium strains that are useful as an anticancer immunotherapeutic. The genetically modified Mycobacterium strains preferably display at least one genetic modification resulting in increased tissue adherence, which can be combined with genetic modifications that increase immunopotency and result in adjuvant production. The invention also provides compositions and methods for the development of said Mycobacterium strains, and pharmaceutic compositions and methods for the use of said Mycobacterium strains as anticancer therapeutics.