HETEROLOGOUS PRODUCTION OF CAPREOMYCIN AND GENERATION OF NEW CAPREOMYCIN DERIVATIVES THROUGH METABOLIC ENGINEERING
摘要
<p>Provided are nucleic acid molecules comprising at least a functional fragment of the capreomycin biosynthetic gene cluster, polypeptides encoded by the cluster and recombinant host cells transformed with any of the nucleic acid molecules disclosed herein. Various methods using any of the vectors or expression cassettes that encode one or more of the gene products of the cluster are provided for heterologous production of capreomycin and capreomycin derivatives.</p>
申请公布号
WO2008141190(A1)
申请公布日期
2008.11.20
申请号
WO2008US63258
申请日期
2008.05.09
申请人
WISCONSIN ALUMNI RESEARCH FOUNDATION;THOMAS, MICHAEL GEORGE;FELNAGLE, ELIZABETH ANNE;RONDON, MICHELLE RENEE;BERTI, ANDREW DAVID
发明人
THOMAS, MICHAEL GEORGE;FELNAGLE, ELIZABETH ANNE;RONDON, MICHELLE RENEE;BERTI, ANDREW DAVID