摘要 |
Novel methods of inhibiting angiogenesis, lymphangiogenesis, tumorigenesis, inflammation, or metastasis, or promoting apoptosis with compositions that inhibit the apelin/APJ signaling pathway are provided. Also provided are methods of promoting angiogenesis or lymphangiogenesis, or inhibiting apoptosis with compositions comprising an apelin polypeptide or small molecule agonist. The present invention further provides methods for identifying therapeutic agents that affect angiogenesis, lymphangiogenesis, and/or apoptosis.
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