DERIVATIVES OF FLUORENE, ANTHRACENE, XANTHENE, DIBENZOSUBERONE AND ACRIDINE AND USES THEREOF

摘要

Chemical agents, such as disulfonamide derivatives of fluorene, anthracen e, xanthene, dibenzosuberone and acridine, and similar heterocyclic ring str uctures, including salts thereof, that act as anti-cancer and anti-tumor age nts, especially where such agents modulate the activity of the Wnt/.beta.-ca tenin signaling pathway, and serve to reduce .beta.-catenin levels present i n cells, such as cancer cells, or where the agents modulate levels of gene e xpression in cellular systems, including cancer cells, are disclosed, along with methods for preparing such agents, as well as pharmaceutical compositio ns containing such agents as active ingredients and methods of using these a s therapeutic agents.