Therapeutic methods and compositions involving isoflavones

摘要

Therapeutic methods of treatment, compositions and foodstuffs are described which contain isoflavone compounds described bathe general formula I
<Chemistry id="chema01" num="0001"><Image id="ia01" he="30" wi="43" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" /></Chemistry>
in which
Z is H,
R<Sub>1</Sub> is H, or R<Sub>A</Sub>CO where R<Sub>A</Sub> is C<Sub>1-10</Sub> alkyl or an amino acid,
R<Sub>2</Sub> is H, OH, or OR<Sub>B</Sub> where R<Sub>B</Sub> is an amino acid or COR<Sub>A</Sub> where R<Sub>A</Sub>
is as previously defined,
W is H, A is H or OH, and B is selected from
<Chemistry id="chema02" num="0002"><Image id="ia02" he="20" wi="70" file="IMGA0002.TIF" imgContent="chem" imgFormat="TIFF" /></Chemistry>
or
W is H, and A, and B taken together form a six membered ring selected from
<Chemistry id="chema03" num="0003"><Image id="ia03" he="20" wi="59" file="IMGA0003.TIF" imgContent="chem" imgFormat="TIFF" /></Chemistry><Chemistry id="chema04" num="0004"><Image id="ia04" he="20" wi="46" file="IMGA0004.TIF" imgContent="chem" imgFormat="TIFF" /></Chemistry>
or
W, A and B taken with the groups with which they are associated comprise
<Chemistry id="chema05" num="0005"><Image id="ia05" he="28" wi="38" file="IMGA0005.TIF" imgContent="chem" imgFormat="TIFF" /></Chemistry>
or
W and A taken together with the groups with which they are associated comprise
<Chemistry id="chema06" num="0006"><Image id="ia06" he="27" wi="36" file="IMGA0006.TIF" imgContent="chem" imgFormat="TIFF" /></Chemistry>
and B is
<Chemistry id="chema07" num="0007"><Image id="ia07" he="17" wi="41" file="IMGA0007.TIF" imgContent="chem" imgFormat="TIFF" /></Chemistry>
wherein
R<Sub>3</Sub> is H, COR<Sub>A</Sub> where R<Sub>A</Sub> is as previously defined , CO<Sub>2</Sub>R<Sub>C</Sub> where R<Sub>C</Sub> is C<Sub>1-10</Sub> alkyl, or COR<Sub>B</Sub> where R<Sub>B</Sub>, is as previously defined,
R<Sub>4</Sub> is H, COR<Sub>D</Sub> where R<Sub>D</Sub> is H, OH, C<Sub>1-10</Sub> alkyl or an amino acid, CO<Sub>2</Sub>R<Sub>C</Sub> where R<Sub>C</Sub> is as previously defined, COR<Sub>E</Sub> where R<Sub>E</Sub> is H, C<Sub>1-10</Sub> alkyl or an amino acid, COOH, COR<Sub>C</Sub> where R<Sub>C</Sub> is as previously defined, or CONHR<Sub>E</Sub> where R<Sub>E</Sub> is as previously defined,
R<Sub>5</Sub> is H, CO<Sub>2</Sub>R<Sub>C</Sub> where R<Sub>C</Sub> is as previously defined, or
COR<Sub>C</Sub>OR<Sub>E</Sub> where R<Sub>C</Sub> and R<Sub>E</Sub> are as previously defined, and where the two R<Sub>5</Sub> groups are attached to the same group they are the same or different,
R<Sub>6</Sub> is H or hydroxy C<Sub>1-10</Sub> alkyl,
X is preferably O, but may be N or S, and
Y is
<Chemistry id="chema08" num="0008"><Image id="ia08" he="19" wi="29" file="IMGA0008.TIF" imgContent="chem" imgFormat="TIFF" /></Chemistry>
where R<Sub>7</Sub> is H, or C<Sub>1-10</Sub> alkyl.