发明名称 |
Identification of 5HT2A receptor ligands by selective amplification of cells transfected with receptors |
摘要 |
The invention is directed to a method for identifying substances acting as ligands for transfected receptors by using transfected markers to measure receptor/ligand interactions. The present invention also relates to a method of identifying compounds which act as inverse agonists of the 5-HT2A receptor, the method comprising contacting a constitutively active 5-HT2A receptor with at least one test compound and determining any decrease in the amount of basal activity of the receptor so as to identify a test compound which is an inverse agonist of the 5-HT2A receptor. Such inverse agonists may be used in the treatment of schizophrenia and related psychoses.
|
申请公布号 |
US7452682(B2) |
申请公布日期 |
2008.11.18 |
申请号 |
US20060417070 |
申请日期 |
2006.05.03 |
申请人 |
ACADIA PHARMACEUTICALS, INC. |
发明人 |
BRANN MARK R. |
分类号 |
G01N33/566;A61K38/00;C07K14/705;C12N15/85;C12Q1/68 |
主分类号 |
G01N33/566 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|