发明名称 |
Recombinant plasmid and method for expressing hepatitis B viral antigens and virions in vivo |
摘要 |
Disclosed is a recombinant plasmid for expressing hepatitis B viral antigens in vivo, comprising an adeno-associated virus (AVV) vector and a replication-competent hepatitis B virus genome fragment. Mice hydrodynamically injected with the recombinant plasmid of the present invention show persistent expression of hepatitis B viral antigens for more than 6 months in the hepatocytes, thus a immuno-competent mouse model for persistent expression of hepatitis B antigens and also for human chronic hepatitis B virus infection is established, which can be applied in evaluation and elucidation of mechanism of chronic hepatitis and anti-viral drug discovery research.
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申请公布号 |
US7452696(B2) |
申请公布日期 |
2008.11.18 |
申请号 |
US20060553975 |
申请日期 |
2006.10.27 |
申请人 |
NATIONAL TAIWAN UNIVERSITY |
发明人 |
CHEN PEI-JER;HUANG LI-RUNG;WU HUI-LIN;CHEN DING-SHINN |
分类号 |
C12N15/09;A01N63/00;A61K39/12;C12P21/04 |
主分类号 |
C12N15/09 |
代理机构 |
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