发明名称 PROCESS FOR PREPARING CRYSTALLINE POLYMORPH OF A BISULFATE SALT OF A THROMBIN RECEPTOR ANTAGONIST
摘要 A crystalline polymorph of a bislulfate salt of a thrombin receptor antagonist compound, which exhibits a powder x-ray diffraction profile substantially the same as that shown in FIG. 1, or which exhibits a differential scanning calorimtery profile substantially the same as that shown in FIG. 3, and is represented by the formula for Compound 2: Chemical formula should be inserted here as it appears on the abstract in paper form. and processes for preparing Compound 2 are disclosed. Pharmaceutical compositions comprising the polymorph of the bisulfate salt and at least one excipient or carrier, and methods of using the polymorph of Compound 2 to treat a variety of physiological disorders, such as thrombosis, are also disclosed.
申请公布号 KR20080100497(A) 申请公布日期 2008.11.18
申请号 KR20087026473 申请日期 2005.01.07
申请人 SCHERING CORPORATION 发明人 THIRUVENGADAM TIRUVETTIPURAM K.;WU WENXUE;WANG TAO;CHIU JOHN S.;BOGDANOWICH KNIPP SUSAN;PAVLOVSKY ANASTASIA;GREENLEE WILLIAM J.;GRAZIANO MICHAEL P.;KOSOGLOU TEDDY;CHINTALA MADHU;CHACKALAMANNIL SAMUEL
分类号 C07D405/06;A61P7/02;A61P9/00;A61P9/04;A61P9/06;A61P9/10;A61P9/12;A61P13/12;A61P35/00;A61P43/00;C07D405/14;C07D413/14;C07D417/14;C07D521/00 主分类号 C07D405/06
代理机构 代理人
主权项
地址