发明名称 |
Antagonistic analogs of GH RH (2003) |
摘要 |
There is provided a novel series of synthetic antagonistic analogs of hGH-RH(1-29)NH<SUB>2</SUB>. These analogs inhibit the activity of endogenous hGH-RH on the pituitary GH-RH receptors, and therefore prevent the release of growth hormone. The analogs also inhibit the proliferation of human cancers through a direct effect on the cancer cells. The higher inhibitory potencies of the new analogs, as compared to previously described ones, results from replacement of various amino acids.
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申请公布号 |
US7452865(B2) |
申请公布日期 |
2008.11.18 |
申请号 |
US20040566776 |
申请日期 |
2004.07.26 |
申请人 |
THE ADMINISTRARE'S OF THE TULANE EDUCATIONAL FUND;UNITED STATES OF AMERICA BY DEPT OF VETERANS AFFAIRS |
发明人 |
SCHALLY ANDREW V.;VARGA JOZSEF;ZARANDI MARTA;CAI REN ZHI |
分类号 |
A61K38/00;A61K38/16;A61K38/25;C07K;C07K14/00;C07K14/60 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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