发明名称 |
Chemical process for the preparation of intermediates to obtain N-formyl hydroxy-lamine compounds |
摘要 |
Improved processes for preparing intermediates useful for preparing antibacterial N-[1-oxo-2-alkyl-3-(N-hydroxyformamido)-propyl}-(carbonylamino-aryl or -heteroaryl)-azacyclo4-7alkanes or thiazacyclo4-7alkanes, which have one or more of the following features: (1) make use of a particular beta-lactam intermediate; (2) which make use of a particular resolving agents, enantiomerically pure substituted propionic acids, especially (R)-2-butyl-3-hydroxy-propionic acid; (3) which avoid the use of hydrogen peroxide; and (4) which facilitate selective debenzylation reducing production of waste by-products.
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申请公布号 |
US7452999(B2) |
申请公布日期 |
2008.11.18 |
申请号 |
US20040544919 |
申请日期 |
2004.02.20 |
申请人 |
NOVARTIS AG |
发明人 |
PRASHAD MAHAVIR;KIM HONG-YONG;HU BIN;SLADE JOEL;KAPA PRASAD KOTESWARA;GIRGIS MICHAEL JOHN |
分类号 |
C07D417/00;A61P31/04;C07C51/487;C07C239/20;C07D207/00;C07D277/00;C07D317/44;C07D401/00;C07D401/12;C07D405/00 |
主分类号 |
C07D417/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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