| 摘要 |
The present invention aims at providing a process for producing an amic acid ester useful as an intermediate for agrochemical, easily at a low cost industrially. The present invention provides a process for producing an amic acid ester represented by the following general formula (7): (see formula 7) (wherein A is a substituted or unsubstituted lower alkylene group or the like; R1 is a substituted or unsubstituted lower alkyl group or the like; and R3 is a hydrogen atom or a lower alkyl group), which process comprises reacting, in the presence of water, an amino acid represented by the following general formula (1): (see formula 1) (wherein A has the same definition as given above) with a halogenated carbonic acid ester represented by the following general formula (2): (see formula 2) (wherein R1 has the same definition as given above and X is a halogen atom) to form an amide compound represented by the following general formula (3): (see formula 3) (wherein A and R1 have the same definitions as given above), then reacting the amide compound with a halogenated carbonic acid ester represented by the following general formula (4): (see formula 4) (wherein R2 is a substituted or unsubstituted lower alkyl group or the like; and X is a halogen atom) to form, in thesystem, a mixed a cid anhydride represented by the following general formula (5): (see formula 5) (wherein A, R1 and R2 have the same definitions as given above), and reacting the mixed acid anhydride with an amine compound represented by the following general formula (6): (see formula 6) (wherein R3 has the same definition as given above and Het is a substituted or unsubstituted heterocyclic group).
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